Products of conception
A range of fragmented endometrial specimens are received in the laboratory; diagnostic curettings and biopsies, products of conception from simple incomplete or complete abortions and post-partum retained products.1,2
This protocol includes products of conception. A separate protocol is provided for endometrial curettings.
Record the patient identifying information and any clinical information supplied together with the specimen description as designated on the container. See overview page for more detail on identification principles.
- Non-routine fixation (not formalin), describe.
- Special studies required, describe.
- Ensure samples are taken prior to fixation.
Fresh specimens may require cytogenetic studies for the investigation of repeated miscarriages or suspected molar pregnancy.
Specimens should be strained through a sieve to ensure all tissue is collected.
See general information for more detail on specimen handling procedures.
Inspect the specimen and dictate a macroscopic description.
Describe the following features of the specimen:
Describe as stated by the clinician.
- Products of conception
- Post-partum retained products
- Other, specify
- Measure aggregate size in three dimensions (mm)
Specimen description if relevant
- Vesicles, if present record diameter (mm)
- Blood clots
Identifiable products of conception
Record the presence of:
- Chorionic villi
- Gestational sac and contents
- Fetal parts. If identified, measure foot length (mm) if possible.
Submit representative tissue including placental tissue and membranes. One or two blocks may suffice for confirmation of normal products of conception. Further blocks may be required if the initial section has failed to confirm intrauterine pregnancy or there is a suspicion of trophoblastic disease or malignancy.
Transfer directly into cassettes for processing. Lens paper, biopsy pads or similar are required to prevent loss of tissue during processing.
Check the pot carefully, particularly the lid and around the rim so that all fragments of tissue are found.
Be aware that blood clot and mucus may not survive processing.
Record details of each cassette.
An illustrated block key similar to the one provided may be useful.
Block allocation key
No. of pieces
Products of conception
Drs Kerryn Ireland-Jenkin and Marsali Newman for their contribution in reviewing and editing this protocol.