The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Full blood count, Blood film, White cell count differential, Platelet count.
Vitamin B12 and Folate assays (RBC).
Bone marrow aspiration only occasionally required for diagnosis and/or confirmation.
Review clinical features for likely cause.
Methylmalonate, plasma, urine, homocysteine or holotranscobalamin have not been shown to be better predictors of response to treatment than the total serum vitamin B12 concentration. Their levels fluctuate with time and neither predict nor preclude cobalamin responsive haematological disorders*.
Lack of intrinsic factor
Intrinsic Factor Ab is specific but positive in only 60% of patients. Parietal cell antibodies have low specificity.
See also Blind loop syndrome, below.
Competition for dietary B12
Absence of ileal receptors for intrinsic factor/B12
* Laurence Solomon: Blood 2005: 105(3), 978 - 985
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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