The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: 17 OH Progesterone, 17-OHP, Hydroxy progesterone
Steroids
5 mL blood in SST/serum tube. Some laboratories may offer an assay on dried blood spot on filter paper.
Immunoassay, LC-MS/MS
Collect pre dose specimen (trough) if patient on therapy for CAH.
Depends on age and phase of cycle (higher in luteal phase) - consult pathologist.
Diagnosis, monitoring and management of congenital adrenal hyperplasia (CAH).
Increased in some rare adrenal tumours.
Included in neonatal screening programs.
In mildly affected patients, measurement after adrenal stimulation with Synacthen® may be required to confirm the diagnosis.
An increased level indicates 21-hydroxylase deficiency.
In patients with CAH due to 21-hydroxylase deficiency, monitoring treatment may require levels at various times of the day. Levels should not be markedly elevated and should not be suppressed immediately prior to the next dose of glucocorticoid.
Auer MK. Congenital adrenal hyperplasia. Lancet 2023; 401: 227-44.
Honour JW. 17-Hydroxyprogesterone in children, adolescents and adults. Ann Clin Biochem 2014; 51: 424-40.
Pathology Tests Explained - 17-hydroxyprogesterone
MBS Rebatable see Medical Benefits Scheme Category 6 Pathology Services
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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