The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
Donate online now using the button below. All donations $2 and over are fully tax deductible. RCPA Foundation thanks you for your generous support. All funds raised will be allocated to the RCPA Foundation Pathology Education Outreach Fellowship.
Eve Propper Events and Sponsorship Manager Ph: +61 2 8356 5806 Fax: +61 2 8356 5828 Email: evep@rcpa.edu.au
Rachel Johnson Events and Grants Coordinator Ph: +61 2 8356 5852 Fax: +61 2 8356 5828 Email: rachelj@rcpa.edu.au
Keywords: von Willebrand, Collagen Binding Assay, CBA, VWF:CB
3mL blood (adult) or 1mL blood (paediatric) in citrate tube. Check with laboratory.
Immunoassay (EIA; ELISA) or chemiluminescence (CLIA) with measure of binding of von Willebrand factor to collagen-coated microtitre plates (ELISA) or magnetic particles (CLIA). Abbreviated VWF:CB.
Refer to the laboratory.
Generally 50-200% of the level in pooled normal plasma (guide only).
Often reported as U/dL.
Additional functional VWF complementary to the platelet glycoprotein Ib binding assays such as the ristocetin cofactor assay in the investigation of a possible bleeding disorder, diagnosis of von Willebrand disease and its variant forms.
See von Willebrand factor activity, Ristocetin cofactor [VWF:RCo], VWF:GPIbR, VWF:GPIbM and von Willebrand factor multimer.
Generally performed in conjunction with other tests and not performed or interpreted in isolation.
See also von Willebrand disease testing; von Willebrand factor Ag, VWF:RCo, VWF:GPIbR, and VWF:GPIbM.
Favaloro EJ, Dean E, Arunachalam S. Evaluating Performance of Contemporary and Historical von Willebrand Factor (VWF) Assays in the Laboratory Identification of von Willebrand Disease (VWD): The Australasian Experience. Semin Thromb Hemost. 2022; 48(6): 711-31.
Favaloro EJ. Navigating the Myriad of von Willebrand Factor Assays. Hamostaseologie. 2020; 40(4): 431-42.
Favaloro EJ. The Role of the von Willebrand Factor Collagen-Binding Assay (VWF:CB) in the Diagnosis and Treatment of von Willebrand Disease (VWD) and Way Beyond: A Comprehensive 36-Year History. Semin Thromb Hemost. 2023 Feb 20; (Epub ahead of print).
MBS Rebatable see Medical Benefits Scheme Category 6 Pathology Services
Page last updated:
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
Royal College of Pathologists of Australasia © 2024 . Apart from any use that is permitted under the Copyright Act 1968 (Cth), and any permissions explicitly granted by Royal College of Pathologists of Australasia, all other rights are reserved.